2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate

Base Information

Chemical Name:2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate
CAS No.:166520-16-7
Molecular Formula:C₁₈H₂₅Cl₂N₅O₄
Molecular Weight:446.334
Hs Code.:

Synonyms:2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate

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Chemical Property of 2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate

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Technology Process of 2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate

There total 7 articles about 2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 166520-14-5
3S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-nitro-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate

: 166520-16-7
2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate

Guidance literature:: With thiophene; hydrogen; platinum on activated charcoal; In methanol; at 50 ℃; for 3h; under 2585.7 Torr;
DOI:10.1080/00397919508011814

Reference yield:

: 112257-24-6
tert-butyl 3-(aminocarbonyl)piperazine-1-carboxylate

: 166520-16-7
2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: Tris buffer pH 8.2 / 168 h / Ambient temperature; L-leucine aminopeptidase

2: NH₃ / methanol / 72 h / 0 °C

3: methanol / 1 h / Ambient temperature

4: Et₃N / dimethylformamide / 1.5 h

5: H₂, thiophene / 5percent Pt/C / methanol / 3 h / 50 °C / 2585.7 Torr

With thiophene; Tris buffer pH 8.2; ammonia; hydrogen; triethylamine; platinum on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1080/00397919508011814

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 166520-16-7
2S-(-)-1,1-dimethylethyl 3-aminocarbonyl-4-<<<(4-amino-2,6-dichlorophenyl)amino>carbonyl>methyl>-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: methanol / 1 h / Ambient temperature

2: Et₃N / dimethylformamide / 1.5 h

3: H₂, thiophene / 5percent Pt/C / methanol / 3 h / 50 °C / 2585.7 Torr

With thiophene; hydrogen; triethylamine; platinum on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1080/00397919508011814