(7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Base Information

Chemical Name:(7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate
CAS No.:1363481-01-9
Molecular Formula:C₄₃H₅₁N₄O₁₄PS
Molecular Weight:910.936
Hs Code.:

(7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Synonyms:(7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Suppliers and Price of (7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

There total 20 articles about (7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1363480-97-0
di-tert-butyl (2-(1-(hydroxymethyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indole-7-carbonylamino)ethyl) phosphate

: 1939-99-7
benzenesulfonyl chloride

: 1363481-01-9
(7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: With pyridine; at 0 ℃; for 1h;
DOI:10.1021/jm201717y

Reference yield:

: 885227-29-2
tert-butyl 1-(chloromethyl)-7-cyano-1,2-dihydro-3H-benzo[e]indole-3-carboxylate

: 1363481-01-9
(7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 12 steps

1.1: trifluoroacetic acid / dichloromethane / 20 °C

2.1: pyridine / 2 h / 0 °C

3.1: sodium iodide / butanone / Reflux

4.1: acetic acid / 48 h / Reflux

5.1: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

6.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C

7.1: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 20 °C

8.1: sodium nitrite / trifluoroacetic acid / 0.25 h / 0 - 20 °C

9.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

9.2: 1 h / 0 - 20 °C

10.1: methanol; caesium carbonate / 0.67 h / 0 °C

11.1: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

12.1: pyridine / 1 h / 0 °C

With pyridine; methanol; sulfuric acid; dihydrogen peroxide; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium iodide; sodium nitrite; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; acetic acid; dimethyl sulfoxide; butanone; trifluoroacetic acid;
DOI:10.1021/jm201717y

Reference yield:

: tert-butyl (1-bromo-6-cyanonaphthalen-2-yl)carbamate

: 1363481-01-9
(7-((2-((di-tert-butoxyphosphoryl)oxy)ethyl)carbamoyl)-5-nitro-3-(5,6,7-trimethoxy-1H-indole-2-carbonyl)-2,3-dihydro-1H-benzo[e]indol-1-yl)methyl phenylmethanesulfonate

Guidance literature:: Multi-step reaction with 12 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 72 h / 0 - 20 °C

2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / benzene / 5 h / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

4.1: pyridine / 4 h / 0 °C

5.1: sulfuric acid; potassium nitrate / 0.45 h / -10 °C

6.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 20 °C

7.1: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 20 °C

8.1: sodium nitrite / trifluoroacetic acid / 0.25 h / 0 - 20 °C

9.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C

9.2: 1 h / 0 - 20 °C

10.1: methanol; caesium carbonate / 0.67 h / 0 °C

11.1: toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl acetamide / 2 h / 20 °C

12.1: pyridine / 1 h / 0 °C

With pyridine; methanol; 2,2'-azobis(isobutyronitrile); sulfuric acid; dihydrogen peroxide; tri-n-butyl-tin hydride; sodium hydride; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium nitrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium nitrite; In tetrahydrofuran; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; trifluoroacetic acid; mineral oil; benzene;
DOI:10.1021/jm201717y