(R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Base Information

Chemical Name:(R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile
CAS No.:1616371-81-3
Molecular Formula:C₂₈H₂₅F₄N₅
Molecular Weight:507.534
Hs Code.:

Synonyms:(R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Chemical Property of (R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

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Technology Process of (R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

There total 10 articles about (R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 452-62-0
3-bromo-4-fluorotoluene

: 1616371-80-2
(R)-4-((1-cyclobutylethyl)amino)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 1616371-81-3
(R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 1616371-82-4
(R)-4-((1-cyclobutylethyl)amino)-7-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: With palladium diacetate; cesium fluoride; trimethylpyruvic acid; catacxium A; In 1,4-dioxane; at 70 - 120 ℃; for 24h; Inert atmosphere;

Reference yield:

: 677743-79-2,1355969-30-0
(1R)-1-cyclobutylethan-1-amine hydrogen chloride salt

: 1616371-81-3
(R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 1616371-82-4
(R)-4-((1-cyclobutylethyl)amino)-7-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 80 °C / Sealed tube

2: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 24 h / 70 - 110 °C / Inert atmosphere

3: palladium diacetate; catacxium A; trimethylpyruvic acid; cesium fluoride / 1,4-dioxane / 24 h / 70 - 120 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; triethylamine; cesium fluoride; trimethylpyruvic acid; catacxium A; XPhos; In 1,4-dioxane; ethanol; N,N-dimethyl acetamide;

Reference yield:

: 1616371-79-9
(R)-2-chloro-N-(1-cyclobutylethyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine

: 1616371-81-3
(R)-4-((1-cyclobutylethyl)amino)-6-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

: 1616371-82-4
(R)-4-((1-cyclobutylethyl)amino)-7-(2-fluoro-5-methylphenyl)-5-(4-(trifluoromethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidine-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: XPhos; bis(η3-allyl-μ-chloropalladium(II)) / N,N-dimethyl acetamide / 24 h / 70 - 110 °C / Inert atmosphere

2: palladium diacetate; catacxium A; trimethylpyruvic acid; cesium fluoride / 1,4-dioxane / 24 h / 70 - 120 °C / Inert atmosphere

With bis(η3-allyl-μ-chloropalladium(II)); palladium diacetate; cesium fluoride; trimethylpyruvic acid; catacxium A; XPhos; In 1,4-dioxane; N,N-dimethyl acetamide;