{(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester

Base Information

Chemical Name:{(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester
CAS No.:180967-91-3
Molecular Formula:C₁₇H₂₆N₂O₅
Molecular Weight:338.404
Hs Code.:

Synonyms:{(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester

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Chemical Property of {(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester

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Technology Process of {(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester

There total 1 articles about {(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1149-26-4
(S)-N-(benzyloxycarbonyl)valine

: 929-06-6
2-(2-Aminoethoxy)ethanol

: 180967-91-3
{(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 24h; Ambient temperature;
DOI:10.1021/jm950641i

Reference yield: 84.0%

: 98-59-9
p-toluenesulfonyl chloride

: 180967-91-3
{(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester

: 180967-95-7
Toluene-4-sulfonic acid 2-[2-((S)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-ethoxy]-ethyl ester

Guidance literature:: With pyridine; In dichloromethane; at 0 - 20 ℃; for 12h;
DOI:10.1021/jm950641i

Reference yield:

: 180967-91-3
{(S)-1-[2-(2-Hydroxy-ethoxy)-ethylcarbamoyl]-2-methyl-propyl}-carbamic acid benzyl ester

: 1053746-39-6
(2R,3R,4S)-2-(3-{2-[2-((S)-2-Amino-3-methyl-butyrylamino)-ethoxy]-ethoxy}-benzylamino)-4-tert-butoxycarbonylamino-3-hydroxy-5-phenyl-pentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / pyridine / CH₂Cl₂ / 12 h / 0 - 20 °C

2: 45 percent / K₂CO₃, tetrabutylammonium iodide / dimethylsulfoxide / 4 h / 70 °C

3: 86 percent / hydroxyammonium chloride, aq. AcONa / ethanol / 1.5 h / 60 °C

4: 48 percent / formic acid, H₂ / 10percent Pd/C / methanol / 3 h / 760 Torr

5: 55 percent / ethanol / 24 h / 80 °C

6: 0.4 M aq. LiOH / dioxane / 16 h / Ambient temperature

With pyridine; lithium hydroxide; formic acid; hydroxylamine hydrochloride; hydrogen; sodium acetate; tetra-(n-butyl)ammonium iodide; potassium carbonate; palladium on activated charcoal; In 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm950641i