1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide

Base Information

Chemical Name:1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide
CAS No.:1207203-67-5
Molecular Formula:C₃₄H₃₈ClF₄N₃O₅S
Molecular Weight:712.205
Hs Code.:

1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide

Synonyms:1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide

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Chemical Property of 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide

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Technology Process of 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide

There total 11 articles about 1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207203-32-4
4-[(3,3,3-Trifluoropropyl)amino]piperidine-4-carboxamide

: 1207203-62-0
5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thiophene-2-carboxylic acid

: 1207203-67-5
1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 104-01-8
4-Methoxyphenylacetic acid

: 1207203-67-5
1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 1.5 h / -60 °C / Inert atmosphere

1.2: -60 - 0 °C

2.1: tetrahydrofuran / 3 h / Reflux

3.1: trichlorophosphate / dichloromethane / 45 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 - 60 °C

5.1: boron tribromide / dichloromethane / -50 - 20 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 7 h / 60 °C

7.1: sodium hydroxide / water; methanol / 2 h / Reflux

7.2: pH 2

8.1: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3 h / 20 °C

With sodium hexamethyldisilazane; boron tribromide; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 288154-18-7
tert-butyl 4-amino-4-carbamoylpiperidine-1-carboxylate

: 1207203-67-5
1-{[5-(2-Chloro-4-fluorophenyl)-4-{4-[3-(tetrahydro-2H-pyran-2-yloxy)propoxy]phenyl}thien-2-yl]carbonyl}-4-[(3,3,3-trifluoropropyl)amino]piperidine-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 3 h / 20 °C

2: hydrogenchloride; methanol / diethyl ether

3: triethylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / dichloromethane / 3 h / 20 °C

With hydrogenchloride; methanol; sodium tris(acetoxy)borohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; triethylamine; In diethyl ether; dichloromethane;