2,6-bis(2-aminophenylsulfanyl methyl) pyridine

Base Information

• Chemical Name: 2,6-bis(2-aminophenylsulfanyl methyl) pyridine
• CAS No.: 156695-47-5
• Molecular Formula: C₁₉H₁₉N₃S₂
• Molecular Weight: 353.512
• Mol file: 156695-47-5.mol

Synonyms:2,6-bis(2-aminophenylsulfanyl methyl) pyridine

Chemical Property of 2,6-bis(2-aminophenylsulfanyl methyl) pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,6-bis(2-aminophenylsulfanyl methyl) pyridine

There total 5 articles about 2,6-bis(2-aminophenylsulfanyl methyl) pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2,6-bis[(tosyloxy)methyl]pyridine (112633-26-8) + 2-amino-benzenethiol (137-07-5) → 2,6-bis(2-aminophenylsulfanyl methyl) pyridine (156695-47-5)

Guidance literature:

With sodium; In ethanol; at 60 ℃; for 3h;

DOI:10.1007/s10847-012-0282-x

Reference yield: 82.0%

2,6-bis-(bromomethyl)pyridine (7703-74-4) + 2-amino-benzenethiol (137-07-5) → 2,6-bis(2-aminophenylsulfanyl methyl) pyridine (156695-47-5)

Guidance literature:

2-amino-benzenethiol; With sodium ethanolate; In ethanol; at 20 ℃; for 0.5h; Inert atmosphere;

2,6-bis-(bromomethyl)pyridine; In ethanol; for 4h; Reflux; Inert atmosphere;

DOI:10.1080/10426500801907589

Reference yield:

Pyridine-2,6-dicarboxylic acid (499-83-2) → 2,6-bis(2-aminophenylsulfanyl methyl) pyridine (156695-47-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid / benzene / 12 h / Reflux; Dean-Stark

2: sodium tetrahydroborate / tetrahydrofuran / 12 h

3: potassium hydroxide / dichloromethane

4: sodium / ethanol / 3 h / 60 °C

With sodium tetrahydroborate; sulfuric acid; sodium; potassium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; benzene;

DOI:10.1007/s10847-012-0282-x

upstream raw materials:

2,6-bis-(bromomethyl)pyridine

2-amino-benzenethiol

2,6-bis[(tosyloxy)methyl]pyridine

Pyridine-2,6-dicarboxylic acid