(S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester

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Chemical Name:(S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester
CAS No.:123993-21-5
Molecular Formula:C₃₄H₃₉NO₆
Molecular Weight:557.687
Hs Code.:

Synonyms:(S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester

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Chemical Property of (S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester

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Technology Process of (S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester

There total 3 articles about (S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 123993-19-1
(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<<(trifluoromethyl)sulfonyl>oxy>benzenepropanoic acid diphenylmethyl ester

: 123993-21-5
(S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester

Guidance literature:: With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 90 ℃; for 24h;
DOI:10.1021/jo00290a021

Reference yield:

: bis(triphenylphosphine)palladium(II) dichloride

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 123993-19-1
(S)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<<(trifluoromethyl)sulfonyl>oxy>benzenepropanoic acid diphenylmethyl ester

: 123993-21-5
(S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 86937-00-0
(S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-3-(4-hydroxyphenyl)propanoic acid diphenylmethyl ester

: 123993-21-5
(S)-(E)-α-<<(1,1-dimethylethoxy)carbonyl>amino>-4-<3-(1,1-dimethylethoxy)-3-oxo-1-propenyl>benzenepropanoic acid diphenylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 62 percent / triethylamine / CH₂Cl₂ / 1) 0 deg C, 1 h, 2) up to RT, over 1 h

2: 54 percent / triethylamine / bis(triphenylphosphine)palladium dichloride / dimethylformamide / 24 h / 90 °C

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00290a021