4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS No.:1215085-76-9
Molecular Formula:C₁₉H₁₃F₄N₃O₃
Molecular Weight:407.324
Hs Code.:

Synonyms:4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Technology Process of 4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

There total 4 articles about 4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1215085-80-5
4-[2,5-dioxo-4-(4-fluorophenyl)-3-methyl-4-[(2-propenyloxy)methyl]imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

: 1215085-76-9
4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: 4-[2,5-dioxo-4-(4-fluorophenyl)-3-methyl-4-[(2-propenyloxy)methyl]imidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile; With trifluoride dimethyl sulfide complex; In dichloromethane; at 20 ℃; for 7h; Inert atmosphere;

With water; sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 191165-13-6
4-bromo-2-(trifluoromethyl)benzonitrile

: 1215085-76-9
4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 2 h / 160 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With copper(I) oxide; boron dimethyl-trifluoro sulphide; potassium carbonate; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm300281x

Reference yield:

: 1215085-78-1
4-(4-fluorophenyl)-4-[(2-propenyloxy)methyl]imidazolidine-2,5-dione

: 1215085-76-9
4-[2,5-dioxo-4-(4-fluorophenyl)-4-hydroxymethyl-3-methylimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: copper(I) oxide / N,N-dimethyl acetamide / 2 h / 160 °C / Inert atmosphere

2: potassium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

3: boron dimethyl-trifluoro sulphide / dichloromethane / 2 h / 20 °C / Inert atmosphere

With copper(I) oxide; boron dimethyl-trifluoro sulphide; potassium carbonate; In dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm300281x