S-NICOTINE-5-CARBOXALDEHYDE

Base Information

• Chemical Name: S-NICOTINE-5-CARBOXALDEHYDE
• CAS No.: 852238-97-2
• Molecular Formula: C₁₁H₁₄N₂O
• Molecular Weight: 190.245
• Mol file: 852238-97-2.mol

Synonyms:S-NICOTINE-5-CARBOXALDEHYDE

Chemical Property of S-NICOTINE-5-CARBOXALDEHYDE

Chemical Property:

• PSA: 33.20000
• LogP: 1.59870
• Storage Temp.: -20°C Freezer

Purity/Quality:

95% ^*data from raw suppliers

S-(-)-Nicotine-5-carboxaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: S-(-)-Nicotine-5-carboxaldehyde is an active Nicotine analog used for modulating nicotinic acetylcholine receptors.

Technology Process of S-NICOTINE-5-CARBOXALDEHYDE

There total 5 articles about S-NICOTINE-5-CARBOXALDEHYDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(S)-5-(1-methylpyrrolidin-2-yl)-1,4-dihydropyridine-3-carbaldehyde (852238-96-1) → (S)-nicotine-5-carboxaldehyde (852238-97-2)

Guidance literature:

With sulfur; In toluene; for 24h; Heating / reflux;

Reference yield:

(S)-3-formyl-5-(1-methylpyrrolidin-2-yl)-4H-pyridine-1-carboxylic acid methyl ester (852238-95-0) → (S)-nicotine-5-carboxaldehyde (852238-97-2)

Guidance literature:

(S)-3-formyl-5-(1-methylpyrrolidin-2-yl)-4H-pyridine-1-carboxylic acid methyl ester; With TEA; In methanol; at 20 ℃; for 24h;

With sulfur; In methanol; toluene; Heating;

DOI:10.1016/j.tetlet.2005.12.085

Reference yield:

3-(1-methylpyrrolidin-2-yl)-4H-pyridine-1-carboxylic acid methyl ester (852238-94-9) → (S)-nicotine-5-carboxaldehyde (852238-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 54 percent / POCl₃

2.1: TEA / methanol / 24 h / 20 °C

2.2: sulfur / methanol; toluene / Heating

With TEA; trichlorophosphate; In methanol; 1.1: Vilsmeier-Haack formylation;

DOI:10.1016/j.tetlet.2005.12.085

upstream raw materials:

(S)-3-formyl-5-(1-methylpyrrolidin-2-yl)-4H-pyridine-1-carboxylic acid methyl ester

3-(1-methylpyrrolidin-2-yl)-4H-pyridine-1-carboxylic acid methyl ester

(S)-3-(1-methylpyrrolidin-2-yl)-1,4-bis-trimethylsilanyl-1,4-dihydropyridine

nicotin

Downstream raw materials:

altinicline

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 852238-97-2 S-NICOTINE-5-CARBOXALDEHYDE

Send

Send

Metric Ton KG G Pound L ML

Send

Send