Technology Process of pGlu-Phe-(RS)Pheψ(COCH2)Gly-Leu-Met-NH2
There total 7 articles about pGlu-Phe-(RS)Pheψ(COCH2)Gly-Leu-Met-NH2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
acetic acid;
for 0.5h;
Ambient temperature;
DOI:10.1021/jm00152a020
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 72.5 percent / 37percent HCl / acetic acid; H2O / 20 h / 120 °C
2: 69.3 percent / 1 N NaOH / dioxane; H2O / 2 h / 0 - 20 °C
3: 37 percent / 4-dimethylaminopyridine (DMAP), dicyclohexylcarbodiimide (DCC), n-methylmorpholine / ethyl acetate / 1 h / Ambient temperature
4: 73.8 percent / 4 N HCl / acetic acid / 0.5 h / Ambient temperature
5: 60.8 percent / 1-hydroxy-benzotriazole (HOBt), dicyclohexylcarbodiimide (DCC), n-methylmorpholine / dimethylformamide / 1 h / Ambient temperature
6: 86.5 percent / 4 N HCl / acetic acid / 0.5 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; dmap; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
1,4-dioxane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm00152a020
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 60.8 percent / 1-hydroxy-benzotriazole (HOBt), dicyclohexylcarbodiimide (DCC), n-methylmorpholine / dimethylformamide / 1 h / Ambient temperature
2: 86.5 percent / 4 N HCl / acetic acid / 0.5 h / Ambient temperature
With
4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
In
acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00152a020
