3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide

Base Information

• Chemical Name: 3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide
• CAS No.: 1208328-36-2
• Molecular Formula: C₁₂H₉F₃N₂OS
• Molecular Weight: 286.277
• Mol file: 1208328-36-2.mol

Synonyms:3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide

Chemical Property of 3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide

There total 2 articles about 3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

C17H17F3N2O3S (1208328-34-0) → 3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide (1208328-36-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 0.5h; Inert atmosphere;

DOI:10.1002/cmdc.200900373

Reference yield: 78.0%

Methyl 3-aminothiophene-2-carboxylate (22288-78-4) + 3-trifluoromethylaniline (98-16-8) → 3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide (1208328-36-2)

Guidance literature:

3-trifluoromethylaniline; With trimethylaluminum; In toluene; at 20 ℃; for 16h; Inert atmosphere;

Methyl 3-aminothiophene-2-carboxylate; In toluene; at 130 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c5ob00233h

Reference yield: 95.0%

3-pyridinecarboxaldehyde (500-22-1) + 3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide (1208328-36-2) → 3-(pyridin-3-ylmethylamino)-N-[3-(trifluoromethyl)phenyl]thiophene-2-carboxamide (1208328-41-9)

Guidance literature:

3-pyridinecarboxaldehyde; 3-amino-N-(4-chloro-3-(trifluoromethyl)phenyl)thiophene-2-carboxamide; With acetic acid; In methanol; at 23 ℃; for 12h; Inert atmosphere;

With sodium cyanoborohydride; In methanol; at 23 ℃; for 24h; Inert atmosphere;

DOI:10.1002/cmdc.200900373

upstream raw materials:

C₁₇H₁₇F₃N₂O₃S

Methyl 3-aminothiophene-2-carboxylate

3-trifluoromethylaniline

Downstream raw materials:

3-(pyridin-4-ylmethylamino)-N-[3-(trifluoromethyl)phenyl]thiophene-2-carboxamide

3-(pyridin-3-ylmethylamino)-N-[3-(trifluoromethyl)phenyl]thiophene-2-carboxamide

3-(furan-2-ylmethylamino)-N-[3-(trifluoromethyl)phenyl]thiophene-2-carboxamide

3-(benzo[b]thiophen-3-ylmethylamino)-N-[3-(trifluoromethyl)-phenyl]thiophene-2-carboxamide