N-[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHYL]-N-METHYLAMINE

Base Information

• Chemical Name: N-[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHYL]-N-METHYLAMINE
• CAS No.: 852227-87-3
• Molecular Formula: C7H13 N3
• Molecular Weight: 139.2
• Hs Code.: 29331990
• Mol file: 852227-87-3.mol

Synonyms:N-[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHYL]-N-METHYLAMINE

Chemical Property of N-[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHYL]-N-METHYLAMINE

Chemical Property:

• PSA: 29.85000
• LogP: 0.83880
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

N-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-N-methylamine 95% ^*data from reagent suppliers

Safty Information:

• Statements: 22-34
• Safety Statements: 23-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHYL]-N-METHYLAMINE

There total 2 articles about N-[(1,3-DIMETHYL-1H-PYRAZOL-5-YL)METHYL]-N-METHYLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-1,3-trimethyl-1H-pyrazole-5-carboxamide (136679-01-1) → 1-(1,3-dimethyl-1H-pyrazol-5-yl)-N-methylmethanamine (852227-87-3)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at -5 - 50 ℃; for 3h;

DOI:10.1021/jm500261q

Reference yield:

1,3-dimethylpyrazol-5-carboxylic acid (5744-56-9) → 1-(1,3-dimethyl-1H-pyrazol-5-yl)-N-methylmethanamine (852227-87-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 0.5 h / 20 - 50 °C

1.2: 1 h / -10 - 20 °C

2.1: dimethylsulfide borane complex / tetrahydrofuran / 3 h / -5 - 50 °C

With dimethylsulfide borane complex; 1,1'-carbonyldiimidazole; In tetrahydrofuran;

DOI:10.1021/jm500261q

Reference yield:

1-(1,3-dimethyl-1H-pyrazol-5-yl)-N-methylmethanamine (852227-87-3) + (E)-3-(2-((5-methyl-2H-tetrazol-2-yl)methyl)-4-(trifluoromethyl)phenyl)acrylic acid → (E)-N-((1,3-dimethyl-1H-pyrazol-5-yl)methyl)-N-methyl-3-(2-((5-methyl-2H-tetrazol-2-yl)methyl)-4-(trifluoromethyl)phenyl)acrylamide

Guidance literature:

1-(1,3-dimethyl-1H-pyrazol-5-yl)-N-methylmethanamine; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

(E)-3-(2-((5-methyl-2H-tetrazol-2-yl)methyl)-4-(trifluoromethyl)phenyl)acrylic acid; With HATU; In N,N-dimethyl-formamide; at 20 ℃;

upstream raw materials:

N-1,3-trimethyl-1H-pyrazole-5-carboxamide

1,3-dimethylpyrazol-5-carboxylic acid

Downstream raw materials:

C₂₇H₃₄FN₅O₅

C₂₁H₂₄FN₅O₃

2-{1-[(3-amino-6-bromopyrazin-2-yl)oxy]ethyl}-N-[(4-bromo-1,3-dimethyl-1H-pyrazol-5-yl)methyl]-4-fluoro-N-methylbenzamide

Refernces