2-BROMOMETHYL-3,4-DIHYDRO-2H-CHROMEN

Base Information

• Chemical Name: 2-BROMOMETHYL-3,4-DIHYDRO-2H-CHROMEN
• CAS No.: 852181-00-1
• Molecular Formula: C₁₀H₁₁BrO
• Molecular Weight: 227.101
• Hs Code.: 2932999099
• Mol file: 852181-00-1.mol

Synonyms:2-(bromomethyl)chroman;2-(bromomethyl)-3,4-dihydro-2H-chromene;2H-1-Benzopyran, 2-(bromomethyl)-3,4-dihydro-;2-Bromomethylchroman;2-bromomethyl-chroman;

Chemical Property of 2-BROMOMETHYL-3,4-DIHYDRO-2H-CHROMEN

Chemical Property:

• Vapor Pressure: 0.00198mmHg at 25°C
• Refractive Index: 1.562
• Boiling Point: 300.6 °C at 760 mmHg
• Flash Point: 118.7 °C
• PSA: 9.23000
• Density: 1.405 g/cm³
• LogP: 2.77510
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-(Bromomethyl)chroman ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMOMETHYL-3,4-DIHYDRO-2H-CHROMEN

There total 5 articles about 2-BROMOMETHYL-3,4-DIHYDRO-2H-CHROMEN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(S)-2-(4-bromo-3-hydroxybutyl)phenol (955124-71-7) → (R)-2-(bromomethyl)chroman (955124-73-9,852181-00-1)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.75h;

Reference yield:

(S)-1-bromo-4-(2-methoxy-phenyl)butan-2-yl acetate (955124-67-1) → (R)-2-(bromomethyl)chroman (955124-73-9,852181-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: boron tribromide / dichloromethane / -78 - 20 °C

1.2: 0 °C

2.1: hydrogenchloride; methanol / diethyl ether / 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.75 h / 20 °C

With hydrogenchloride; methanol; di-isopropyl azodicarboxylate; boron tribromide; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane;

Reference yield:

(S)-1-bromo-4-(2-hydroxy-phenyl)butan-2-yl acetate (955124-69-3) → (R)-2-(bromomethyl)chroman (955124-73-9,852181-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride; methanol / diethyl ether / 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.75 h / 20 °C

With hydrogenchloride; methanol; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; diethyl ether;

upstream raw materials:

(S)-2-(4-bromo-3-hydroxybutyl)phenol

(S)-1-bromo-4-(2-methoxy-phenyl)butan-2-yl acetate

(S)-1-bromo-4-(2-hydroxy-phenyl)butan-2-yl acetate

(S)-1-(benzyloxy)-4-(2-methoxyphenyl)butan-2-ol

Downstream raw materials:

(2R)-3,4-dihydro-2H-chromen-2-ylmethylamine hydrochloride

Refernces