N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide

Base Information

Chemical Name:N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide
CAS No.:120578-83-8
Molecular Formula:C₂₇H₃₉Cl₂N₂O₄P
Molecular Weight:557.497
Hs Code.:

Synonyms:N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide

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Chemical Property of N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide

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Technology Process of N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide

There total 6 articles about N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 120578-82-7
N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-methoxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide

: 120578-83-8
N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide

Guidance literature:: With boron tribromide; In dichloromethane;
DOI:10.1021/jm00127a023

Reference yield:

: tert-butyl 6-hydroxy-5,6-bis(4-methoxyphenyl)octanoate

: 120578-83-8
N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide

Guidance literature:: Multi-step reaction with 6 steps

1: 45.5 percent / H₂, perchloric acid / Pd/C / acetic acid / 2250.2 Torr

2: dicyclohexyl carbodiimide / tetrahydrofuran

3: 63 percent / Et₃N / tetrahydrofuran / 24 h / Ambient temperature

4: 65 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / Ambient temperature

5: 94 percent / pyridine / 12 h

6: 98 percent / BBr₃ / CH₂Cl₂

With pyridine; lithium aluminium tetrahydride; perchloric acid; hydrogen; boron tribromide; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; acetic acid;
DOI:10.1021/jm00127a023

Reference yield:

: 107036-38-4,120578-47-4,120578-48-5
(5S*,6R*)-5,6-bis(4-methoxyphenyl)-1-octanoic acid

: 120578-83-8
N,N-bis(2-chloroethyl)-N'-(erythro-5,6-bis(4-hydroxyphenyl)-1-octyl)-N',O-propylenephosphoric acid ester diamide

Guidance literature:: Multi-step reaction with 5 steps

1: dicyclohexyl carbodiimide / tetrahydrofuran

2: 63 percent / Et₃N / tetrahydrofuran / 24 h / Ambient temperature

3: 65 percent / lithium aluminum hydride / tetrahydrofuran / 5 h / Ambient temperature

4: 94 percent / pyridine / 12 h

5: 98 percent / BBr₃ / CH₂Cl₂

With pyridine; lithium aluminium tetrahydride; boron tribromide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00127a023