3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole
CAS No.:1236144-64-1
Molecular Formula:C₁₈H₁₀BrF₃N₄O₂
Molecular Weight:451.202
Hs Code.:

Synonyms:3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

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Chemical Property of 3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

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Technology Process of 3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

There total 6 articles about 3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1236144-63-0
5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole

: 1236144-64-1
3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

Guidance literature:: With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile);
DOI:10.1016/j.bmcl.2016.03.105

Reference yield:

: 1236144-60-7
5-(3-(pyridin-2-yl)isoxazol-5-yl)-3-p-tolyl-1,2,4-oxadiazole

: 1236144-64-1
3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; palladium diacetate / acetonitrile

2: copper(l) iodide; N,N,N,N,N,N-hexamethylphosphoric triamide / N,N-dimethyl-formamide

3: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile)

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); palladium diacetate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2016.03.105

Reference yield:

: 439126-55-3
3-(pyridin-2-yl)isoxazole-5-carboxylic acid ethyl ester

: 1236144-64-1
3-(4-(bromomethyl)phenyl)-5-(3-(pyridin-2-yl)-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / Alkaline conditions

2: N-Bromosuccinimide; palladium diacetate / acetonitrile

3: copper(l) iodide; N,N,N,N,N,N-hexamethylphosphoric triamide / N,N-dimethyl-formamide

4: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile)

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; copper(l) iodide; 2,2'-azobis(isobutyronitrile); palladium diacetate; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2016.03.105