Benzoic acid, 2-[[3,5-dichloro-4-[2-[2-(2-pyridinyldithio)ethoxy]ethoxy]phenyl]amino]-

Base Information

Chemical Name:Benzoic acid, 2-[[3,5-dichloro-4-[2-[2-(2-pyridinyldithio)ethoxy]ethoxy]phenyl]amino]-
CAS No.:851962-11-3
Molecular Formula:C₂₂H₂₀Cl₂N₂O₄S₂
Molecular Weight:511.45
Hs Code.:
Mol file:851962-11-3.mol

Synonyms:Benzoic acid, 2-[[3,5-dichloro-4-[2-[2-(2-pyridinyldithio)ethoxy]ethoxy]phenyl]amino]-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Benzoic acid, 2-[[3,5-dichloro-4-[2-[2-(2-pyridinyldithio)ethoxy]ethoxy]phenyl]amino]-

Chemical Property:

Boiling Point:659.4±55.0 °C(Predicted)
PKA:3.62±0.36(Predicted)
Density:1.47±0.1 g/cm3(Predicted)

Purity/Quality:

Safty Information:

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Technology Process of Benzoic acid, 2-[[3,5-dichloro-4-[2-[2-(2-pyridinyldithio)ethoxy]ethoxy]phenyl]amino]-

There total 8 articles about Benzoic acid, 2-[[3,5-dichloro-4-[2-[2-(2-pyridinyldithio)ethoxy]ethoxy]phenyl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 851962-05-5
2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid tert-butyl ester

: 851962-11-3
2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid

Guidance literature:: With trifluoroacetic acid; for 3h;
DOI:10.1021/ja042929f

Reference yield:

: 851962-02-2
tert-butyl 2-(4-benzyloxy-3,5-dichlorophenylamino)benzoate

: 851962-11-3
2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / H₂ / Pd/C / methanol; ethyl acetate / 16 h

2: 76 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h

3: 100 percent / trifluoroacetic acid / 3 h

With di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; 2: Mitsunobu reaction;
DOI:10.1021/ja042929f

Reference yield:

: 55666-42-7
tert-butyl 2-bromobenzoate

: 851962-11-3
2-(3,5-dichloro-4-{2-[2-(pyridin-2-yldisulfanyl)-ethoxy]-ethoxy}-phenylamino)-benzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 58 percent / tris(dibenzylidenoacetone)dipalladium⁽⁰⁾; (R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; cesium carbonate / toluene / 24 h / Heating

2: 89 percent / H₂ / Pd/C / methanol; ethyl acetate / 16 h

3: 76 percent / diisopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 1 h

4: 100 percent / trifluoroacetic acid / 3 h

With tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; di-isopropyl azodicarboxylate; hydrogen; caesium carbonate; (R)-2,2'-bis(diphenylphosphanyl)-1,1'-binaphthyl; triphenylphosphine; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; ethyl acetate; toluene; 3: Mitsunobu reaction;
DOI:10.1021/ja042929f