ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate

Base Information

Chemical Name:ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate
CAS No.:113730-20-4
Molecular Formula:C₁₈H₁₃Cl₂FN₂O₆
Molecular Weight:443.215
Hs Code.:

Synonyms:ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate

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Chemical Property of ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate

Chemical Property:

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Technology Process of ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate

There total 7 articles about ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 113730-18-0
ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-2,3-dihydrobenzofuran-2-carboxylate

: 113730-20-4
ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate

Guidance literature:: With nitric acid; In dichloromethane; at 4 ℃;
DOI:10.1248/cpb.35.3215

Reference yield:

: 62717-20-8
6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid ethyl ester

: 113730-20-4
ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 80 percent / HNO₃ / CH₂Cl₂ / 1.5 h / 4 °C

2: 100 percent / H₂ / palladium carbon (10percent) / ethyl acetate

3: 72 percent / HNO₃ / CH₂Cl₂ / 2 h / 4 - 6 °C

4: 1.) NOSO₄H (45percent); 2.) H₃PO₂ (50percent) / 1.) H₂SO₄, THF, -5 deg C, 2.5 h; 2.) -14 to 15 deg C, 1 h

5: 92 percent / H₂ / Pd-C (10percent) / ethyl acetate

6: 97 percent / 4-N,N-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

7: 55 percent / HNO₃ / CH₂Cl₂ / 4 °C

With dmap; nitrosylsulfuric acid; hydrogen; nitric acid; hypophosphorous acid; palladium on activated charcoal; palladium carbon; In dichloromethane; ethyl acetate;
DOI:10.1248/cpb.35.3215

Reference yield:

: 113730-03-3
ethyl 5-amino-6,7-dichloro-2,3-dihydrobenzofuran-2-carboxylate

: 113730-20-4
ethyl 6,7-dichloro-4-(o-fluorobenzoylamino)-5-nitro-2,3-dihydrobenzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 72 percent / HNO₃ / CH₂Cl₂ / 2 h / 4 - 6 °C

2: 1.) NOSO₄H (45percent); 2.) H₃PO₂ (50percent) / 1.) H₂SO₄, THF, -5 deg C, 2.5 h; 2.) -14 to 15 deg C, 1 h

3: 92 percent / H₂ / Pd-C (10percent) / ethyl acetate

4: 97 percent / 4-N,N-dimethylaminopyridine / CH₂Cl₂ / Ambient temperature

5: 55 percent / HNO₃ / CH₂Cl₂ / 4 °C

With dmap; nitrosylsulfuric acid; hydrogen; nitric acid; hypophosphorous acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1248/cpb.35.3215