2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile

Base Information

Chemical Name:2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile
CAS No.:864661-53-0
Molecular Formula:C₁₅H₁₅ClN₂O₂
Molecular Weight:290.749
Hs Code.:

Synonyms:2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile

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Chemical Property of 2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile

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Technology Process of 2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile

There total 7 articles about 2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 864661-63-2
C₂₂H₁₉ClN₂O₃

: 864661-53-0
2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; methanol; at 0 ℃; for 3h;
DOI:10.1021/jm070312d

Reference yield:

: 627531-48-0
N-(3-chloro-4-cyano-2-methylphenyl)acetamide

: 864661-53-0
2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / conc. HCl; EtOH / 0.5 h / Heating

2: 39 percent / CuI; tert-butylnitrite / acetonitrile / 3 h / 65 °C

3: 21 percent / K₃PO₄ / CuI; 1,2-cyclohexyldiamine / dioxane / 14 h / 110 °C

4: 88 percent / KOH / tetrahydrofuran; methanol / 3 h / 0 °C

With hydrogenchloride; potassium hydroxide; potassium phosphate; copper(l) iodide; tert.-butylnitrite; ethanol; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;
DOI:10.1021/jm070312d

Reference yield:

: 573768-09-9
4-amino-2-chloro-3-methyl-benzonitrile

: 864661-53-0
2-chloro-4-((3aR,4R,6aS)-4-hydroxy-1-oxo-hexahydrocyclopenta[c]pyrrol-2-(1H)-yl)-3-methylbenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 39 percent / CuI; tert-butylnitrite / acetonitrile / 3 h / 65 °C

2: 21 percent / K₃PO₄ / CuI; 1,2-cyclohexyldiamine / dioxane / 14 h / 110 °C

3: 88 percent / KOH / tetrahydrofuran; methanol / 3 h / 0 °C

With potassium hydroxide; potassium phosphate; copper(l) iodide; tert.-butylnitrite; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; methanol; acetonitrile;
DOI:10.1021/jm070312d