1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione

Base Information

Chemical Name:1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione
CAS No.:1062616-91-4
Molecular Formula:C₂₃H₂₀F₂O₄
Molecular Weight:398.406
Hs Code.:

Synonyms:1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione

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Chemical Property of 1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione

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Technology Process of 1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione

There total 8 articles about 1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1062616-71-0
1-(3-bromo-phenyl)-2-(3-cyclopropyl-4-difluoromethoxy-phenyl)-ethane-1,2-dione

: 115-19-5
2-methyl-but-3-yn-2-ol

: 1062616-91-4
1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione

Guidance literature:: With triethylamine; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; at 80 ℃; for 1h; Microwave irradiation;

Reference yield:

: 1062615-36-4
2-bromo-1-difluoromethoxy-4-iodo-benzene

: 1062616-91-4
1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 6 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 0 °C

2: potassium phosphate / palladium diacetate; tricyclohexylphosphine / water; toluene / 6 h / 100 °C

3: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 - 20 °C

4: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 0 °C

5: potassium permanganate; sodium carbonate; magnesium sulfate / water; acetone / 2 h / 20 °C

6: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1 h / 80 °C / Microwave irradiation

With potassium phosphate; potassium permanganate; copper(l) iodide; tetrabutyl ammonium fluoride; sodium carbonate; magnesium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tricyclohexylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

: 1062615-44-4
2-cyclopropyl-1-difluoromethoxy-4-ethynyl-benzene

: 1062616-91-4
1-(3-cyclopropyl-4-(difluoromethoxy)phenyl)-2-(3-(3-hydroxy-3-methylbut-1-ynyl)phenyl)ethane-1,2-dione

Guidance literature:: Multi-step reaction with 3 steps

1: copper(l) iodide; triethylamine / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 2 h / 0 °C

2: potassium permanganate; sodium carbonate; magnesium sulfate / water; acetone / 2 h / 20 °C

3: triethylamine / copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1 h / 80 °C / Microwave irradiation

With potassium permanganate; copper(l) iodide; sodium carbonate; magnesium sulfate; triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; acetone;