[3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester

Base Information

• Chemical Name: [3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester
• CAS No.: 581106-32-3
• Molecular Formula: C₂₆H₄₂NO₉P
• Molecular Weight: 543.595
• Mol file: 581106-32-3.mol

Synonyms:[3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester

Chemical Property of [3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester

There total 3 articles about [3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

1-chloroethyl pivalate (40258-80-8) + [3-[acetyl(phenylmethoxy)amino]propyl]phosphonic acid (581106-29-8) → [3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester (581106-32-3)

Guidance literature:

With triethylamine; sodium iodide; In various solvent(s); at 60 ℃; for 6h;

DOI:10.1002/ardp.200500976

Reference yield:

O-(benzylhydroxylamino)propylphosphonic acid diethyl ester (557090-55-8) → [3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester (581106-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 83 percent / Et₃N / CH₂Cl₂ / 20 °C

2.1: bromotrimethylsilane / 20 °C

2.2: 83 percent / water / 20 °C

3.1: 38 percent / Et₃N; NaI / various solvent(s) / 6 h / 60 °C

With trimethylsilyl bromide; triethylamine; sodium iodide; In dichloromethane;

DOI:10.1002/ardp.200500976

Reference yield:

[3-[acetyl(phenylmethoxy)amino]propyl]phosphonic acid diethyl ester (581106-28-7) → [3-[acetyl(phenylmethoxy)amino]propyl]-phosphonic acid bis[1-(2,2-dimethylpropionyloxy)ethyl] ester (581106-32-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bromotrimethylsilane / 20 °C

1.2: 83 percent / water / 20 °C

2.1: 38 percent / Et₃N; NaI / various solvent(s) / 6 h / 60 °C

With trimethylsilyl bromide; triethylamine; sodium iodide; In various solvent(s);

DOI:10.1002/ardp.200500976

upstream raw materials:

1-chloroethyl pivalate

[3-[acetyl(phenylmethoxy)amino]propyl]phosphonic acid

O-(benzylhydroxylamino)propylphosphonic acid diethyl ester

[3-[acetyl(phenylmethoxy)amino]propyl]phosphonic acid diethyl ester