Technology Process of 4,6-dichloro-2-<(E)-6',7'-dihydroxy-3',7'-dimethyl-2'-octenyl>-5-methyl-1,3-cyclohexanedione-6',7'-acetonide
There total 7 articles about 4,6-dichloro-2-<(E)-6',7'-dihydroxy-3',7'-dimethyl-2'-octenyl>-5-methyl-1,3-cyclohexanedione-6',7'-acetonide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-chloro-succinimide; calcium carbonate;
In
1,2-dimethoxyethane; water;
Ambient temperature;
DOI:10.1016/0040-4020(82)85107-7
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-methylmorpholine-N-oxide, OsO4, NaHSO3 / acetone; H2O; 2-methyl-propan-2-ol / 12 h / 50 °C
2: p-TsOH, MgSO4 / benzene / Ambient temperature
3: 95 percent / K2CO3 / methanol; H2O / 6 h / Ambient temperature
4: 86 percent / PBr3 / diethyl ether / 0.33 h / -5 °C
5: 1) t-BuLi, 2) NH4Cl aq. / 1) THF, /-60 -(-)70 degC/, 30 min, 2) -20 deg C
6: 39 percent / NCS, CaCO3 / 1,2-dimethoxy-ethane; H2O / Ambient temperature
With
N-chloro-succinimide; osmium(VIII) oxide; tert.-butyl lithium; phosphorus tribromide; magnesium sulfate; potassium carbonate; ammonium chloride; toluene-4-sulfonic acid; sodium hydrogensulfite; 4-methylmorpholine N-oxide; calcium carbonate;
In
methanol; 1,2-dimethoxyethane; diethyl ether; water; acetone; tert-butyl alcohol; benzene;
DOI:10.1016/0040-4020(82)85107-7
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 1) t-BuLi, 2) NH4Cl aq. / 1) THF, /-60 -(-)70 degC/, 30 min, 2) -20 deg C
2: 39 percent / NCS, CaCO3 / 1,2-dimethoxy-ethane; H2O / Ambient temperature
With
N-chloro-succinimide; tert.-butyl lithium; ammonium chloride; calcium carbonate;
In
1,2-dimethoxyethane; water;
DOI:10.1016/0040-4020(82)85107-7
