6-[[4-(4-Morpholinylsulfonyl)benzyl]amino]benzo[CD]indol-2(1H)-one

Base Information

Chemical Name:6-[[4-(4-Morpholinylsulfonyl)benzyl]amino]benzo[CD]indol-2(1H)-one
CAS No.:138385-02-1
Molecular Formula:C₂₂H₂₁N₃O₄S
Molecular Weight:423.492
Hs Code.:
DSSTox Substance ID:DTXSID101141551

Synonyms:DTXSID101141551;6-[[4-(4-MORPHOLINYLSULFONYL)BENZYL]AMINO]BENZO[CD]INDOL-2(1H)-ONE;138385-02-1;Benz[cd]indol-2(1H)-one, 6-[[[4-(4-morpholinylsulfonyl)phenyl]methyl]amino]-

Suppliers and Price of 6-[[4-(4-Morpholinylsulfonyl)benzyl]amino]benzo[CD]indol-2(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[[4-(4-Morpholinylsulfonyl)benzyl]amino]benzo[CD]indol-2(1H)-one

Chemical Property:

XLogP3:2.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:5
Exact Mass:423.12527733
Heavy Atom Count:30
Complexity:725

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1COCCN1S(=O)(=O)C2=CC=C(C=C2)CNC3=C4C=CC=C5C4=C(C=C3)NC5=O

Technology Process of 6-[[4-(4-Morpholinylsulfonyl)benzyl]amino]benzo[CD]indol-2(1H)-one

There total 8 articles about 6-[[4-(4-Morpholinylsulfonyl)benzyl]amino]benzo[CD]indol-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 50964-11-9
6-aminobenzindol-2(1H)-one

: 138385-04-3
4-((4-(bromomethyl)benzene)sulfonyl)morpholine

: 138385-02-1
N⁶-<4-(morpholinosulfonyl)benzyl>-6-aminobenzindol-2(1H)-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h;
DOI:10.1021/jm00082a006

Reference yield:

: 130-00-7
1,8-naphtholactam

: 138385-02-1
N⁶-<4-(morpholinosulfonyl)benzyl>-6-aminobenzindol-2(1H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / 70percent HNO₃ / acetic acid / 1 h / 20 - 50 °C

2: H₂ / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr

3: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h

With hydrogen; nitric acid; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a006

Reference yield:

: 28434-96-0
N-hydroxy-4-nitro-1,8-naphthalimide

: 138385-02-1
N⁶-<4-(morpholinosulfonyl)benzyl>-6-aminobenzindol-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: Na₂CO₃ / H₂O / 1 h / Heating

2: NaOH / ethanol; H₂O / 16 h / 25 °C

3: H₂ / 5percent Pd/C / tetrahydrofuran / 16 h / 2068.6 Torr

4: 75 percent / DIEA / dimethylformamide / a) 105 deg C, 1.5 h, b) 85 deg C, 1.5 h

With sodium hydroxide; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00082a006