ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate

Base Information

Chemical Name:ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate
CAS No.:1421015-70-4
Molecular Formula:C₃₀H₃₁NO₆
Molecular Weight:501.579
Hs Code.:

Synonyms:ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate

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Chemical Property of ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate

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Technology Process of ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate

There total 3 articles about ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 103-82-2
phenylacetic acid

: 575505-40-7
ethyl N-[7-(4-methoxyphenoxy)-6-methylindan-4-yl]malonamate

: 1421015-70-4
ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate

Guidance literature:: With trifluoromethylsulfonic anhydride; In dichloromethane; at 20 ℃; for 15h;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: 575505-01-0
[7-(4-methoxyphenoxy)-6-methylindan-4-yl]amine

: 1421015-70-4
ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 3 h / 20 °C

2: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; In dichloromethane; 2: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: bis(4-methoxyphenyl)iodonium tetrafluoroborate

: 1421015-70-4
ethyl N-[7-(4-methoxy-3-phenylacetylphenoxy)-6-methylindan-4-yl]malonamate

Guidance literature:: Multi-step reaction with 4 steps

1: copper; triethylamine / dichloromethane / 120 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

3: pyridine / dichloromethane / 3 h / 20 °C

4: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; hydrogen; copper; triethylamine; In dichloromethane; ethyl acetate; 4: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002