(R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol

Base Information

Chemical Name:(R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol
CAS No.:1352790-08-9
Molecular Formula:C₁₅H₂₂F₃NO₂
Molecular Weight:305.34
Hs Code.:

Synonyms:(R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol

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Chemical Property of (R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol

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Technology Process of (R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol

There total 5 articles about (R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 109-72-8,29786-93-4
n-butyllithium

: (4R)-2-hydroxymethyl-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

: 1352790-08-9
(R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol

Guidance literature:: n-butyllithium; (4R)-2-hydroxymethyl-2-trifluoromethyl-4-phenyl-1,3-oxazolidine; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; optical yield given as %de; diastereoselective reaction;
DOI:10.1021/ol2032174

Reference yield:

: (4R)-2-hydroxymethyl-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

: 1352790-08-9
(R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

Reference yield:

: 1094092-25-7
(4R)-2-ethoxycarbonyl-2-trifluoromethyl-4-phenyl-1,3-oxazolidine

: 1352790-08-9
(R)-2-(((R)-2-hydroxy-1-phenylethyl) amino)-2-(trifluoromethyl)hexan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / methanol / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

With sodium tetrahydroborate; In tetrahydrofuran; methanol;
DOI:10.1021/ol2032174