methyl(phenyl)vinylsilylacetic acid

Base Information

• Chemical Name: methyl(phenyl)vinylsilylacetic acid
• CAS No.: 1269600-99-8
• Molecular Formula: C₁₁H₁₄O₂Si
• Molecular Weight: 206.316
• Mol file: 1269600-99-8.mol

Synonyms:methyl(phenyl)vinylsilylacetic acid

Chemical Property of methyl(phenyl)vinylsilylacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl(phenyl)vinylsilylacetic acid

There total 3 articles about methyl(phenyl)vinylsilylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

trimethylsilyl acetate (2754-27-0) + phenyl methyl vinyl chlorosilane (17306-05-7) → methyl(phenyl)vinylsilylacetic acid (1269600-99-8)

Guidance literature:

trimethylsilyl acetate; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2.25h; Inert atmosphere;

phenyl methyl vinyl chlorosilane; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

With hydrogenchloride; water; In tetrahydrofuran; pH=1;

DOI:10.1016/j.tet.2010.12.020

Reference yield:

phenyl methyl vinyl chlorosilane (17306-05-7) → methyl(phenyl)vinylsilylacetic acid (1269600-99-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / 2 h / -78 °C

1.2: 2 h / -78 °C

2.1: Acidic conditions

With lithium diisopropyl amide;

DOI:10.1021/jo200254z

Reference yield:

C14H22O2Si2 → methyl(phenyl)vinylsilylacetic acid (1269600-99-8)

Guidance literature:

Acidic conditions;

DOI:10.1021/jo200254z

upstream raw materials:

trimethylsilyl acetate

phenyl methyl vinyl chlorosilane

Downstream raw materials:

1,2-bis[methyl(vinyl)phenylsilyl]ethane