(+)-(2R,4S)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester

Base Information

Chemical Name:(+)-(2R,4S)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester
CAS No.:575433-00-0
Molecular Formula:C₁₉H₁₇NO₃
Molecular Weight:307.349
Hs Code.:

Synonyms:(+)-(2R,4S)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester

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Chemical Property of (+)-(2R,4S)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester

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Technology Process of (+)-(2R,4S)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester

There total 2 articles about (+)-(2R,4S)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 140-29-4
phenylacetonitrile

: (S)-2-Chlorocarbonyl-2-phenyl-propionic acid methyl ester

: 575433-00-0
(+)-(2R,4S)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester

: (2R,4R)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester

Guidance literature:: phenylacetonitrile; With sodium hydride; In tetrahydrofuran; for 2h; Heating;

(S)-2-Chlorocarbonyl-2-phenyl-propionic acid methyl ester; In tetrahydrofuran; at 0 - 20 ℃; for 10h;
DOI:10.1021/ol0347803

Reference yield:

: 116140-69-3
(+)-(R)-2-methyl-2-phenylmalonic acid monomethyl ester

: 575433-00-0
(+)-(2R,4S)-4-cyano-2-methyl-3-oxo-2,4-diphenylbutyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl chloride; DMF / CH₂Cl₂ / 2 h / 20 °C

2.1: NaH / tetrahydrofuran / 2 h / Heating

2.2: tetrahydrofuran / 10 h / 0 - 20 °C

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ol0347803