trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Base Information

Chemical Name:trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid
CAS No.:1415571-46-8
Molecular Formula:C₂₅H₂₇F₃N₄O₃
Molecular Weight:488.51
Hs Code.:

Synonyms:trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

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Chemical Property of trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

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Technology Process of trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

There total 15 articles about trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1415574-03-6
trans-ethyl 4-((1-(5-(5-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylate

: 1415571-46-8
trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 40 ℃;
DOI:10.1021/ml5003426

Reference yield:

: 3618-04-0,75877-66-6,17159-80-7
4-hydroxycyclohexyl carboxylic acid ethyl ester

: 1415571-46-8
trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C

2: ChiralPak AD-H / Resolution of racemate

3: hydrogen; acetic acid / platinum(IV) oxide

4: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 110 °C

5: water; lithium hydroxide monohydrate / tetrahydrofuran / 40 °C

With lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; acetic acid; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;

Reference yield:

: 626-64-2,157061-69-3
pyridin-4-ol

: 1415571-46-8
trans-4-((1-(5-(5-(trifluoromethyl)-1Hbenzo[d]imidazol-2-yl)pyridin-2-yl)piperidin-4-yl)oxy)cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: triphenylphosphine; di-isopropyl azodicarboxylate / tetrahydrofuran / 48 h / 55 °C

2: ChiralPak AD-H / Resolution of racemate

3: hydrogen; acetic acid / platinum(IV) oxide

4: sodium hydrogencarbonate / 1-methyl-pyrrolidin-2-one / 110 °C

5: water; lithium hydroxide monohydrate / tetrahydrofuran / 40 °C

With lithium hydroxide monohydrate; di-isopropyl azodicarboxylate; water; hydrogen; sodium hydrogencarbonate; acetic acid; triphenylphosphine; platinum(IV) oxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one;