5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide

Base Information

Chemical Name:5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide
CAS No.:1584301-65-4
Molecular Formula:C₂₃H₂₇N₃O₇
Molecular Weight:457.483
Hs Code.:

Synonyms:5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide

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Chemical Property of 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide

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Technology Process of 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide

There total 7 articles about 5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1584301-56-3
5-(2,4-dihydroxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide

: 108-24-7
acetic anhydride

: 1584301-65-4
5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.ejmech.2014.01.056

Reference yield:

: C₁₄H₂₁N₃O₄

: 1584301-65-4
5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / Reflux

2: hydrogenchloride / water / Reflux

3: methanol / 12 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C

5: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.01.056

Reference yield:

: 32161-06-1
1-acetyl-4-piperidinone

: 1584301-65-4
5-(2,4-diacetoxy-5-isopropylbenzoyl)-N-ethyl-4,5,6,7-tetrahydroisoxazole[4,5-c]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: toluene-4-sulfonic acid / toluene / Reflux

2: triethylamine / dichloromethane

3: trifluoroacetic acid / dichloromethane / Reflux

4: hydrogenchloride / water / Reflux

5: methanol / 12 h

6: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 20 °C

7: pyridine / dichloromethane / 4 h / 20 °C

With pyridine; hydrogenchloride; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2014.01.056