2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester

Base Information

Chemical Name:2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester
CAS No.:436809-82-4
Molecular Formula:C₃₈H₄₇ClN₄O₇S
Molecular Weight:739.333
Hs Code.:

2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester

Synonyms:2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester

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Chemical Property of 2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester

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Technology Process of 2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester

There total 11 articles about 2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 436809-80-2
(4-aminomethyl-phenyl)-[4-(4-chloro-phenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-methanone

: 436809-88-0
(R)-5-(((S)-1-(tert-butoxy)-1-oxopropan-2-yl)amino)-4-[(tert-butoxycarbonyl)amino]-5-oxo-pentanoic acid

: 436809-82-4
2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester

Guidance literature:: (R)-5-(((S)-1-(tert-butoxy)-1-oxopropan-2-yl)amino)-4-[(tert-butoxycarbonyl)amino]-5-oxo-pentanoic acid; With 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

(4-aminomethyl-phenyl)-[4-(4-chloro-phenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]-methanone; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/S0968-0896(01)00066-9

Reference yield:

: 1711-02-0
4-iodobenzoic acid chloride

: 436809-82-4
2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2.1: i-PrMgBr / tetrahydrofuran / 1 h / -15 °C

2.2: 97 percent / tetrahydrofuran / 3 h / -15 °C

3.1: 87 percent / NaBH₄ / methanol / 0.42 h / 0 - 20 °C

4.1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

5.1: 100 percent / NaN₃ / dimethylformamide / 24 h / 20 °C

6.1: 64 percent / H₂ / Pd/C / methanol / 3 h / 20 °C

7.1: 1-hydroxybenzotriazole hydrate; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

7.2: 76 percent / dimethylformamide / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; isopropylmagnesium bromide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00066-9

Reference yield:

: 213462-12-5
4-(4-chlorophenyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine

: 436809-82-4
2-(2-tert-butoxycarbonylamino-4-{4-[4-(4-chlorophenyl)-6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl]benzyl-carbamoyl}butyrylamino)propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 86 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2.1: i-PrMgBr / tetrahydrofuran / 1 h / -15 °C

2.2: 97 percent / tetrahydrofuran / 3 h / -15 °C

3.1: 87 percent / NaBH₄ / methanol / 0.42 h / 0 - 20 °C

4.1: 99 percent / SOCl₂ / CH₂Cl₂ / 1 h / 0 °C

5.1: 100 percent / NaN₃ / dimethylformamide / 24 h / 20 °C

6.1: 64 percent / H₂ / Pd/C / methanol / 3 h / 20 °C

7.1: 1-hydroxybenzotriazole hydrate; N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

7.2: 76 percent / dimethylformamide / 20 °C

With sodium tetrahydroborate; thionyl chloride; sodium azide; hydrogen; isopropylmagnesium bromide; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(01)00066-9