3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea

Base Information

• Chemical Name: 3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea
• CAS No.: 77081-29-9
• Molecular Formula: C₉H₁₆ClN₃O₂
• Molecular Weight: 235.682
• Mol file: 77081-29-9.mol

Synonyms:3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea

Chemical Property of 3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea

There total 3 articles about 3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)urea (77081-26-6) → 3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea (77081-29-9)

Guidance literature:

With formic acid; sodium nitrite; at 0 - 5 ℃; for 0.5h;

DOI:10.1021/jo00325a011

Reference yield:

Cyclohexyl isocyanate (3173-53-3) → 3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea (77081-29-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / diethyl ether / 12 h / Ambient temperature

2: 41 percent / SOCl₂ / 1 h / Heating

3: 74 percent / 1.) anhydrous NaNO₂/anhydrous HCOOH / 0.5 h / 0 - 5 °C

With formic acid; thionyl chloride; sodium nitrite; In diethyl ether;

DOI:10.1021/jo00325a011

Reference yield:

3-Cyclohexyl-1-(1,1-dideuterio-2-hydroxyethyl)urea (77081-27-7) → 3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)-1-nitrosourea (77081-29-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / SOCl₂ / 1 h / Heating

2: 74 percent / 1.) anhydrous NaNO₂/anhydrous HCOOH / 0.5 h / 0 - 5 °C

With formic acid; thionyl chloride; sodium nitrite;

DOI:10.1021/jo00325a011

upstream raw materials:

3-Cyclohexyl-1-(1,1-dideuterio-2-chloroethyl)urea

3-Cyclohexyl-1-(1,1-dideuterio-2-hydroxyethyl)urea

Cyclohexyl isocyanate

Downstream raw materials:

d1-vinyl chloride

1,1-dideuterio-1,2-dichloroethane

2-chloro-2,2-dideuterioethanol

<1,1-(2)H2>-2-Chloroethanol