di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate

Base Information

Chemical Name:di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate
CAS No.:156078-99-8
Molecular Formula:C₂₅H₃₉ClN₂O₉S
Molecular Weight:579.112
Hs Code.:

Synonyms:di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate

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Chemical Property of di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate

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Technology Process of di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate

There total 3 articles about di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 32677-01-3
L-glutamic acid di-tert-butyl ester hydrochloride

: 156078-99-8
di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate

Guidance literature:: Multi-step reaction with 4 steps

1: 82 percent / Et₃N / CHCl₃ / 5 h / Ambient temperature

2: 83 percent / ammonium formate / 10percent Pd/C / ethanol / 0.33 h / Ambient temperature

3: AcOH / 22 h / Ambient temperature

4: 43 percent / pyridine / a) 2 deg C, 20 min, b) 50 deg C, 10 min

With pyridine; ammonium formate; acetic acid; triethylamine; palladium on activated charcoal; In ethanol; chloroform;
DOI:10.1021/jm00026a013

Reference yield:

: 156079-00-4
di-tert-butyl <<(4-nitrophenyl)oxy>carbonyl>-L-glutamate

: 156078-99-8
di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / ammonium formate / 10percent Pd/C / ethanol / 0.33 h / Ambient temperature

2: AcOH / 22 h / Ambient temperature

3: 43 percent / pyridine / a) 2 deg C, 20 min, b) 50 deg C, 10 min

With pyridine; ammonium formate; acetic acid; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00026a013

Reference yield:

: 172974-17-3
di-tert-butyl <<(4-aminophenyl)oxy>carbonyl>-L-glutamate

: 156078-99-8
di-tert-butyl <<<4-<(2-chloroethyl)<2-(mesyloxy)ethyl>amino>phenyl>oxy>carbonyl>-L-glutamate

Guidance literature:: Multi-step reaction with 2 steps

1: AcOH / 22 h / Ambient temperature

2: 43 percent / pyridine / a) 2 deg C, 20 min, b) 50 deg C, 10 min

With pyridine; acetic acid;
DOI:10.1021/jm00026a013