(2-chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone

Base Information

Chemical Name:(2-chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone
CAS No.:1139875-74-3
Molecular Formula:C₂₀H₂₀ClN₅OS
Molecular Weight:413.931
Hs Code.:

Synonyms:(2-chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone

Suppliers and Price of (2-chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem
5mg
$ 200.00

Cayman Chemical
GSK3β Inhibitor XVIII
25mg
$ 613.00

Cayman Chemical
GSK3β Inhibitor XVIII
10mg
$ 280.00

Cayman Chemical
GSK3β Inhibitor XVIII
5mg
$ 158.00

Cayman Chemical
GSK3β Inhibitor XVIII
1mg
$ 35.00

AK Scientific
(2-Chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone
25mg
$ 927.00

Total 1 raw suppliers

Chemical Property of (2-chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone

Chemical Property:

Purity/Quality:

≥98% ^*data from raw suppliers

GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

Technology Process of (2-chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone

There total 1 articles about (2-chloro-4-(4-(thiophen-2-yl)pyrimidin-2-ylamino)phenyl)(4-methylpiperazin-1-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: