Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate

Base Information

Chemical Name:Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate
CAS No.:1226862-07-2
Molecular Formula:C₂₈H₂₂F₃N₅O₄
Molecular Weight:549.509
Hs Code.:

Synonyms:Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate

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Chemical Property of Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate

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Technology Process of Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate

There total 1 articles about Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1225380-81-3
C₂₀H₁₆F₃N₅O₂

: 501-53-1,94274-21-2
benzyl chloroformate

: 1226862-07-2
Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 4h; Inert atmosphere;

Reference yield: 64.0%

: 1226862-07-2
Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate

: 7250-67-1
1-(2-chloroethyl)pyrrolidine hydrochloride

: 1226862-08-3
Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}[2-(pyrrolidin-1-yl)ethyl]carbamate

Guidance literature:: Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.166667h; Inert atmosphere;

1-(2-chloroethyl)pyrrolidine hydrochloride; In N,N-dimethyl-formamide; mineral oil; at 80 ℃; for 4h;

Reference yield:

: 1226862-07-2
Benzyl {3-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]phenyl}carbamate

: 1226861-97-7
3-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]-N-[2-(pyrrolidin-1-yl)ethyl]aniline

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 20 °C / Inert atmosphere

1.2: 4 h / 80 °C

2.1: hydrogenchloride / water / 168 h / 50 - 60 °C

With hydrogenchloride; sodium hydride; In water; N,N-dimethyl-formamide; mineral oil;