(2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane

Base Information

• Chemical Name: (2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane
• CAS No.: 250229-62-0
• Molecular Formula: C₂₇H₄₀O₃Si
• Molecular Weight: 440.698
• Mol file: 250229-62-0.mol

Synonyms:(2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane

Chemical Property of (2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane

There total 2 articles about (2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

tert-butylchlorodiphenylsilane (58479-61-1) + (2R,6S)-7-acetoxy-2,6-dimethyl-1-heptanol (173690-81-8) → (2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane (250229-62-0)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1002/(sici)1099-0690(199909)1999:9<2175::aid-ejoc2175>3.0.co;2-v

Reference yield:

2,6-dimethyl-1,7-heptanediol (40325-99-3) → (2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane (250229-62-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Lipase PS / tetrahydrofuran / 72 h / 0 °C

2: 96 percent / imidazole / dimethylformamide / 4 h / 20 °C

With 1H-imidazole; Lipase PS; In tetrahydrofuran; N,N-dimethyl-formamide; 1: Esterification / 2: Silylation;

DOI:10.1002/(sici)1099-0690(199909)1999:9<2175::aid-ejoc2175>3.0.co;2-v

Reference yield: 99.0%

(2S,6R)-1-acetoxy-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptane (250229-62-0) → (2S,6R)-7-tert-butyldiphenylsilyloxy-2,6-dimethyl-1-heptanol (101382-88-1)

Guidance literature:

With potassium carbonate; In methanol; at 20 ℃; for 5h;

DOI:10.1002/(sici)1099-0690(199909)1999:9<2175::aid-ejoc2175>3.0.co;2-v

upstream raw materials:

tert-butylchlorodiphenylsilane

(2R,6S)-7-acetoxy-2,6-dimethyl-1-heptanol

2,6-dimethyl-1,7-heptanediol

Downstream raw materials:

(2S,6R)-7-tert-butyldiphenylsilyloxy-2,6-dimethyl-1-heptanol

(2S,6R)-7-tert-butyldiphenylsilyloxy-2,6-dimethylheptanal

(2S/R,3S,7R)-8-tert-butyldiphenylsilyloxy-3,7-dimethyl-2-octanol

(2R,6S,7R/S)-2,6-dimethyl-7-tetrahydropyranyloxyoctyl tosylate