(1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide

Base Information

Chemical Name:(1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide
CAS No.:93454-87-6
Molecular Formula:C₁₄H₂₁NO₃
Molecular Weight:251.326
Hs Code.:

Synonyms:(1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide

Chemical Property:

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Technology Process of (1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide

There total 3 articles about (1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 93454-86-5
(1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-<(tert-butyldimethylsilyl)oxy>propionamide

: 93454-87-6
(1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide

Guidance literature:: With acetic acid; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jo00200a038

Reference yield:

: 321-98-2,7009-81-6,90-83-5,6912-63-6
(1S,2R)-(+)-ephedrine

: 93454-87-6
(1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / tetrahydrofuran / 2 h / Irradiation

2: 1.)O₃, 2.)NaBH₄ / 1.)abs. methanol, -78 deg C, 2.)0 deg C, 1 h

With sodium tetrahydroborate; ozone; In tetrahydrofuran;
DOI:10.1021/jo00200a038

Reference yield:

: 93454-82-1,93528-77-9,93528-80-4,93528-81-5
(1'R,2'S,2S)-N-(2'-Hydroxy-1'-methyl-2'-phenylethyl)-8-oxo-N,2,4,6-tetramethylnona-3,5-dienamide

: 93454-87-6
(1'R,2'S,2S)-N,2-Dimethyl-N-(2'-hydroxy-1'-methyl-2'-phenylethyl)-3-hydroxypropionamide

Guidance literature:: With sodium tetrahydroborate; ozone; Yield given. Multistep reaction; 1.)abs. methanol, -78 deg C, 2.)0 deg C, 1 h;
DOI:10.1021/jo00200a038