3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride

Base Information

Chemical Name:3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride
CAS No.:97871-08-4
Molecular Formula:C₂₃H₂₆N₂O₆*ClH
Molecular Weight:462.93
Hs Code.:

Synonyms:3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride

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Chemical Property of 3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride

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Technology Process of 3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride

There total 6 articles about 3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 97871-05-1
(S)-2-((S)-9-Benzyloxycarbonylmethyl-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-ylamino)-4-phenyl-butyric acid ethyl ester

: 97871-08-4
3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; Ambient temperature;
DOI:10.1248/cpb.34.1128

Reference yield:

: 2021-28-5
ethyl dihydrocinnamate

: 97871-08-4
3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaOMe; 2) 15 percent H₂SO₄ / 1) MeOH, 60-70 deg C, 1.5 h; 2) reflux 15 h

2: ethanol; H₂SO₄ / 5 h / Heating

3: 40 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

4: 85 percent / H₂, HCl / 10 percent Pd-C / ethanol / Ambient temperature

With hydrogenchloride; 4 A molecular sieve; sulfuric acid; hydrogen; sodium methylate; sodium cyanoborohydride; palladium on activated charcoal; In ethanol; sulfuric acid; acetic acid;
DOI:10.1248/cpb.34.1128

Reference yield:

: 710-11-2
2-oxo-4-phenylbutyric acid

: 97871-08-4
3(S)-[1(S)-ethoxycarbonyl-3-phenylpropyl]amino-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-5-acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol; H₂SO₄ / 5 h / Heating

2: 40 percent / NaBH₃CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature

3: 85 percent / H₂, HCl / 10 percent Pd-C / ethanol / Ambient temperature

With hydrogenchloride; 4 A molecular sieve; hydrogen; sodium cyanoborohydride; palladium on activated charcoal; In ethanol; sulfuric acid; acetic acid;
DOI:10.1248/cpb.34.1128