(S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

Base Information

• Chemical Name: (S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate
• CAS No.: 97534-38-8
• Molecular Formula: C₁₉H₁₉F₃O₄
• Molecular Weight: 368.353
• Mol file: 97534-38-8.mol

Synonyms:(S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

Chemical Property of (S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate

There total 2 articles about (S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride (39637-99-5,20445-33-4) + (S)-2-Methyl-2-phenoxy carbinolcid (87860-35-3) → (S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate (97534-38-8)

Guidance literature:

With pyridine; dmap; In benzene; for 7h; Ambient temperature;

DOI:10.1002/hlca.19940770210

Reference yield:

(S)-(?)-ethyl 2-phenoxypropionate (76671-57-3) → (S)-2-phenoxypropyl (R)-3,3,3-trifluoro-2-methoxy-2-phenylpropionate (97534-38-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / LiAlH₄ / diethyl ether / 3 h / Ambient temperature

2: 90 percent / DMAP, pyridine / benzene / 7 h / Ambient temperature

With pyridine; dmap; lithium aluminium tetrahydride; In diethyl ether; benzene;

DOI:10.1002/hlca.19940770210

upstream raw materials:

(S)-(+)-2-methoxy-2-trifluoromethyl-2-phenylacetyl chloride

(S)-2-Methyl-2-phenoxy carbinolcid

(S)-(?)-ethyl 2-phenoxypropionate