diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

Base Information

• Chemical Name: diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate
• CAS No.: 115315-09-8
• Molecular Formula: C₃₁H₃₁N₃O₄
• Molecular Weight: 509.605
• Mol file: 115315-09-8.mol

Synonyms:diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

Chemical Property of diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

There total 1 articles about diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-cyano-7-hydroxy-6-hydroxymethyl-3,12-imino-13-methyl-1,2,3,4,6,11,11a,12-octahydroazepino<1,2-b>isoquinoline-1-carboxylic acid (115362-83-9) + diazodiphenylmethane (908093-98-1) → diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate (115315-09-8)

Guidance literature:

In methanol; chloroform; for 1h;

DOI:10.1248/cpb.38.3202

Reference yield: 78.8%

diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate (115315-09-8) → diphenylmethyl 5-cyano-8,11-dioxo-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,11,12,12a-decahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate (115315-10-1)

Guidance literature:

With potassiuim nitrosodisulfonate; sodium acetate; In acetonitrile;

DOI:10.1248/cpb.38.3202

Reference yield:

diphenylmethyl 5-cyano-8-hydroxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,12,12a-octahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate (115315-09-8) → diphenylmethyl 5-cyano-11-hydroxyimino-7-hydroxymethyl-13-methyl-8-oxo-1,2,3,4,5,7,8,11,12,12a-decahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate (133507-70-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 78.8 percent / Fremy's salt, 1N AcONa / acetonitrile

2: 55 percent / H₂NOH*HCl / methanol

With potassiuim nitrosodisulfonate; hydroxylamine hydrochloride; sodium acetate; In methanol; acetonitrile;

DOI:10.1248/cpb.38.3202

upstream raw materials:

4-cyano-7-hydroxy-6-hydroxymethyl-3,12-imino-13-methyl-1,2,3,4,6,11,11a,12-octahydroazepino<1,2-b>isoquinoline-1-carboxylic acid

diazodiphenylmethane

Downstream raw materials:

diphenylmethyl 5-cyano-8,11-dioxo-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,11,12,12a-decahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

diphenylmethyl 5-cyano-11-hydroxyimino-7-hydroxymethyl-13-methyl-8-oxo-1,2,3,4,5,7,8,11,12,12a-decahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

diphenylmethyl 5-cyano-7-hydroxymethyl-11-methoxyimino-13-methyl-8-oxo-1,2,3,4,5,7,8,11,12,12a-decahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate

diphenylmethyl 5-cyano-8,11-dioxo-9,10-epoxy-7-hydroxymethyl-13-methyl-1,2,3,4,5,7,8,9,10,11,12,12a-dodecahydro-1,4-iminoazepino<1,2-b>isoquinoline-2-carboxylate