(2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

Base Information

• Chemical Name: (2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide
• CAS No.: 900802-88-2
• Molecular Formula: C₁₆H₂₁N₃O₃S
• Molecular Weight: 335.427
• Mol file: 900802-88-2.mol

Synonyms:(2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

Chemical Property of (2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

There total 4 articles about (2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-Amino-3-methyl-N-((S)-2-oxo-tetrahydro-furan-3-yl)-butyramide + phenyl isothiocyanate (103-72-0) → (2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide (900802-88-2)

Guidance literature:

With triethylamine; In ethyl acetate; at 20 ℃; for 3h;

DOI:10.1021/jm060157n

Reference yield:

(2S)-2-((tert-butoxy)carbonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide (602307-60-8) → (2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide (900802-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / ethyl acetate / 18 h / 20 °C

2: Et₃N / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; triethylamine; In ethyl acetate;

DOI:10.1021/jm060157n

Reference yield:

Boc-Val-ONSu (3392-12-9) → (2S)-3-methyl-2-(((phenylamino)thioxomethyl)amino)-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide (900802-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / Et₃N / dimethylformamide / 18 h / 20 °C

2: aq. HCl / ethyl acetate / 18 h / 20 °C

3: Et₃N / ethyl acetate / 3 h / 20 °C

With hydrogenchloride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm060157n

upstream raw materials:

phenyl isothiocyanate

(2S)-2-((tert-butoxy)carbonylamino)-3-methyl-N-((3S)-tetrahydro-2-oxo-3-furanyl)butanamide

Boc-Val-ONSu