7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride

Base Information

Chemical Name:7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride
CAS No.:1609199-62-3
Molecular Formula:C₂₄H₃₂FN₇O₃*ClH
Molecular Weight:522.023
Hs Code.:

Synonyms:7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride

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Chemical Property of 7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride

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Technology Process of 7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride

There total 3 articles about 7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 62933-00-0
7-(3-chloropropyl)-1,3-dimethyl-8-morpholin-4-yl-3,7-dihydropurine-2,6-dione

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 1609199-62-3
7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride

Guidance literature:: 7-(3-chloropropyl)-1,3-dimethyl-8-morpholin-4-yl-3,7-dihydropurine-2,6-dione; 1-(4-Fluorophenyl)piperazine; With potassium carbonate; In propan-1-ol; for 30h; Reflux;

With hydrogenchloride; In acetone;
DOI:10.1016/j.molstruc.2014.03.018

Reference yield:

: 10381-75-6
8-bromotheophylline

: 1609199-62-3
7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: butan-1-ol / Reflux

2: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / acetone / Reflux

3: potassium carbonate / propan-1-ol / 30 h / Reflux

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In propan-1-ol; acetone; butan-1-ol;
DOI:10.1016/j.molstruc.2014.03.018

Reference yield:

: 30958-49-7
1,3-dimethyl-8-morpholin-4-yl-3,7-dihydropurine-2,6-dione

: 1609199-62-3
7-{3-[4-(4-fluorophenyl)piperazin-1-yl]propyl}-1,3-dimethyl-8-(morpholin-4-yl)-3,7-dihydropurine-2,6-dione hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; N-benzyl-N,N,N-triethylammonium chloride / acetone / Reflux

2: potassium carbonate / propan-1-ol / 30 h / Reflux

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; In propan-1-ol; acetone;
DOI:10.1016/j.molstruc.2014.03.018