(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Base Information

• Chemical Name: (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide
• CAS No.: 1417556-38-7
• Molecular Formula: C₂₈H₃₄N₄O₅
• Molecular Weight: 506.602
• Mol file: 1417556-38-7.mol

Synonyms:(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Chemical Property of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide

There total 9 articles about (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-bromoacetamido)-N-methyl-3-phenylpropanamide (1375278-49-1) + 2-(3-isopropyl-5-methyl-1H-pyrazol-4-yl)ethanol (1417557-00-6) → (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide (1417556-38-7)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 12h;

Reference yield:

ethyl 2-(3-isopropyl-5-methyl-1H-pyrazol-4-yl)acetate (1417556-99-0) → (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide (1417556-38-7)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

With lithium aluminium tetrahydride; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

benzo[1,3]dioxolo-5-ylamine (14268-66-7) → (S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-(4-(2-hydroxyethyl)-3-isopropyl-5-methyl-1H-pyrazol-1-yl)acetamido)-N-methyl-3-phenylpropanamide (1417556-38-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium methylate / methanol / 24 h / 20 °C

1.2: 3 h / 40 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C

3.1: hydrogenchloride / methanol / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.75 h / 0 - 20 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 12 h / 80 °C

With hydrogenchloride; sodium methylate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

ethyl 2-(3-isopropyl-5-methyl-1H-pyrazol-4-yl)acetate

(S)-N-(benzo[d][1,3]dioxol-5-yl)-2-(2-bromoacetamido)-N-methyl-3-phenylpropanamide

2-(3-isopropyl-5-methyl-1H-pyrazol-4-yl)ethanol

N-methyl-3,4-(methylenedioxy)aniline