methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

Base Information

Chemical Name:methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate
CAS No.:1228966-45-7
Molecular Formula:C₄₂H₅₀N₈O₆
Molecular Weight:762.909
Hs Code.:

methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

Synonyms:methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

Suppliers and Price of methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

There total 10 articles about methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-((S)-pyrrolidin-2-yl)-5-((4'-(2-((S)-pyrrolidin-2-yl)-1H-imidazol-5-yl)biphenyl-4-yl)ethynyl)-1H-imidazole trifluoroacetate

: 111398-44-8,74761-42-5
N-methoxycarbonyl-L-valine

: 1228966-45-7
methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; for 1h;

Reference yield:

: 69610-41-9,117625-90-8
Boc-L-Pro-H

: 1228966-45-7
methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: ammonium hydroxide / water; methanol / 19 h / 20 °C

2: iodine; sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C / Darkness

3: sodium sulfite / ethanol; water / 20 h / 90 - 100 °C

4: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 60 °C / Inert atmosphere; Sealed tube

5: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 24 h / 80 °C / Inert atmosphere; Sealed tube

6: DCE / 1 h / 20 °C

7: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With ammonium hydroxide; copper(l) iodide; iodine; sodium hydrogencarbonate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium sulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; 1,2-dimethoxyethane; DCE; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1007882-58-7,1332326-40-5
(S)-tert-butyl 2-(1H-imidazol-2-yl)pyrrolidine-1-carboxylate

: 1228966-45-7
methyl ((1S)-1-(((2S)-2-(4-(4'-((2-((2S)-1-((2S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)-2-pyrrolidinyl)-1H-imidazol-4-yl)ethynyl)-4-biphenylyl)-1H-imidazol-2-yl)-1-pyrrolidinyl)carbonyl)-2-methylpropyl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: iodine; sodium carbonate / 1,4-dioxane; water / 16 h / 20 °C / Darkness

2: sodium sulfite / ethanol; water / 20 h / 90 - 100 °C

3: triethylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 60 °C / Inert atmosphere; Sealed tube

4: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 24 h / 80 °C / Inert atmosphere; Sealed tube

5: DCE / 1 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

With copper(l) iodide; iodine; sodium hydrogencarbonate; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium sulfite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; DCE; ethanol; water; N,N-dimethyl-formamide;