(6-(4-tert-butylphenyl)pyrimidin-4-yl)-(2,3-dihydro-benzo[b][1,4]dioxin-6-yl)methanone

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Chemical Name:(6-(4-tert-butylphenyl)pyrimidin-4-yl)-(2,3-dihydro-benzo[b][1,4]dioxin-6-yl)methanone
CAS No.:943997-63-5
Molecular Formula:C₂₃H₂₂N₂O₃
Molecular Weight:374.439
Hs Code.:

Synonyms:(6-(4-tert-butylphenyl)pyrimidin-4-yl)-(2,3-dihydro-benzo[b][1,4]dioxin-6-yl)methanone

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Chemical Property of (6-(4-tert-butylphenyl)pyrimidin-4-yl)-(2,3-dihydro-benzo[b][1,4]dioxin-6-yl)methanone

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Technology Process of (6-(4-tert-butylphenyl)pyrimidin-4-yl)-(2,3-dihydro-benzo[b][1,4]dioxin-6-yl)methanone

There total 2 articles about (6-(4-tert-butylphenyl)pyrimidin-4-yl)-(2,3-dihydro-benzo[b][1,4]dioxin-6-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 659729-07-4
6-[4-(tert-butyl)phenyl]-4-chloropyrimidine

: 29668-44-8
2,3-dihydro-benzo[1,4]dioxin-6-carbaldehyde

: 943997-63-5
(6-(4-tert-butylphenyl)pyrimidin-4-yl)-(2,3-dihydro-benzo[b][1,4]dioxin-6-yl)methanone

Guidance literature:: With sodium hydride; 1,3-dimethylimidazolim iodide; In 1,4-dioxane; for 1h; Heating;
DOI:10.1021/jm070189q

Reference yield:

: 123324-71-0
p-tert-butylphenylboronic acid

: 943997-63-5
(6-(4-tert-butylphenyl)pyrimidin-4-yl)-(2,3-dihydro-benzo[b][1,4]dioxin-6-yl)methanone

Guidance literature:: Multi-step reaction with 2 steps

1: 63 percent / aq. K₂CO₃ / Pd(PPh₃)4 / dioxane / 5 h / 90 °C

2: 58 percent / NaH; 1,3-dimethylimidazolium iodide / dioxane / 1 h / Heating

With sodium hydride; 1,3-dimethylimidazolim iodide; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1: Suzuki coupling;
DOI:10.1021/jm070189q