(2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

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Chemical Name:(2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone
CAS No.:848004-19-3
Molecular Formula:C₂₀H₃₄N₂O₄Si
Molecular Weight:394.586
Hs Code.:

(2-amino-4,5-dimethoxy-phenyl)-[2-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

Synonyms:(2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

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Chemical Property of (2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

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Technology Process of (2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

There total 1 articles about (2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 848004-17-1
C₂₀H₃₂N₂O₆Si

: 848004-19-3
(2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; under 827.459 Torr;

Reference yield:

: 848004-19-3
(2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

: 848004-56-8
2-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenoxycarbonylamino]-pentanedioic acid

Guidance literature:: Multi-step reaction with 5 steps

1: TEA / toluene / 2 h / 20 °C

2: TEA / CH₂Cl₂ / 18 h / 20 °C

3: 91 percent / aq. AcOH / tetrahydrofuran / 3 h / 20 °C

4: 62 percent / pyridinium dichromate; 4 Angstroem sieves / CH₂Cl₂ / 2 h / 20 °C

5: 90 percent / Pd(PPh₃)4; pyrrolidine / CH₂Cl₂ / 20 °C

With pyrrolidine; dipyridinium dichromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4 A molecular sieve; TEA; acetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.10.017

Reference yield:

: 848004-19-3
(2-amino-4,5-dimethoxy-phenyl)-[2-(tert-butyl-dimethyl-silanyloxymethyl)-pyrrolidin-1-yl]-methanone

: 2-{3-[4-(11-hydroxy-7,8-dimethoxy-5-oxo-2,3,11,11a-tetrahydro-1H,5H-benzo[e]pyrrolo[1,2-a][1,4]diazepine-10-carbonyloxymethyl)-phenyl]-ureido}-pentanedioic acid

Guidance literature:: Multi-step reaction with 5 steps

1: TEA / toluene / 2 h / 20 °C

2: TEA / CH₂Cl₂ / 18 h / 20 °C

3: 99 percent / aq. AcOH / tetrahydrofuran / 3 h / 20 °C

4: 57 percent / pyridinium dichromate; 4 Angstroem sieves / CH₂Cl₂ / 2 h / 20 °C

5: 87 percent / Pd(PPh₃)4; pyrrolidine / CH₂Cl₂ / 20 °C

With pyrrolidine; dipyridinium dichromate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4 A molecular sieve; TEA; acetic acid; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1016/j.bmcl.2005.10.017