Ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate

Base Information

Chemical Name:Ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate
CAS No.:850348-88-8
Molecular Formula:C₁₃H₁₆O₅
Molecular Weight:252.267
Hs Code.:2932999099
DSSTox Substance ID:DTXSID10592244
Wikidata:Q82486251
Mol file:850348-88-8.mol

Synonyms:850348-88-8;Ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate;Ethyl-3-([1,3]dioxolan-2-ylmethoxy)-benzoate;ethyl 3-(1,3-dioxolan-2-ylmethoxy)benzoate;Benzoic acid,3-(1,3-dioxolan-2-ylmethoxy)-, ethyl ester;Ethyl 3-[(1,3-dioxolan-2-yl)methoxy]benzoate;ETHYL-3-([1,3]DIOXOLAN-2-YLMETHOXY)BENZOATE;SCHEMBL2743575;DTXSID10592244;WHUHWYZQAUTDRM-UHFFFAOYSA-N;AKOS015969185;AS-69799;DB-319572;CS-0330909;Ethyl3-((1,3-dioxolan-2-yl)methoxy)benzoate;W18239;3-([1,3]-dioxolan-2-ylmethoxy)-benzoic acid ethylester;3-([1,3]Dioxolan-2-ylmethoxy)-benzoic acid ethyl ester;3-[(1,3)dioxolan-2-ylmethoxy]benzoic acid ethyl ester;3-([1, 3]Dioxolan-2-ylmethoxy)-benzoic acid ethyl ester;3-([1,3]-dioxolan-2-ylmethoxy)-benzoic acid ethyl ester

Suppliers and Price of Ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of Ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate

Chemical Property:

PSA：53.99000
LogP:1.61500
XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:252.09977361
Heavy Atom Count:18
Complexity:262

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CC(=CC=C1)OCC2OCCO2

Technology Process of Ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate

There total 1 articles about Ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 4360-63-8
2-bromomethyl-1,3-dioxolane

: 7781-98-8
ethyl-3-hydroxybenzoate

: 850348-88-8
ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 120 ℃; for 18h;
DOI:10.1039/c4cc05107f

Reference yield:

: 850348-88-8
ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate

: 3-(2-(aminooxy)-2-azidoethoxy)-N-(2-(5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl)benzamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: trimethylsilylazide; tin(IV) chloride / 2 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / diethyl ether / 24 h / 20 °C / Cooling with ice; Inert atmosphere

4.1: sodium hydroxide / ethanol

5.1: triethylamine / N,N-dimethyl-formamide / 0.5 h / 20 °C

6.1: N,N-dimethyl-formamide / 2 h / 0 - 20 °C / Inert atmosphere

7.1: hydrogenchloride / methanol / 1.5 h / 40 °C

With hydrogenchloride; trimethylsilylazide; tin(IV) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium hydroxide; In methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c4cc05107f

Reference yield:

: 850348-88-8
ethyl 3-((1,3-dioxolan-2-yl)methoxy)benzoate

: ethyl 3-(2-azido-2-((methylsulfonyl)oxy)ethoxy)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trimethylsilylazide; tin(IV) chloride / 2 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

With trimethylsilylazide; tin(IV) chloride; triethylamine; In dichloromethane;
DOI:10.1039/c4cc05107f