4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

Base Information

Chemical Name:4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate
CAS No.:804498-92-8
Molecular Formula:C₂₅H₂₈O₅
Molecular Weight:408.494
Hs Code.:

Synonyms:4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

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Chemical Property of 4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

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Technology Process of 4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

There total 4 articles about 4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2,2-dimethyl-propionic acid 4-(2,5-dimethoxy-phenyl)-1-ethoxythiocarbonylsulfanyl-4-oxo-butyl ester

: 804498-92-8
4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

Guidance literature:: Multi-step reaction with 2 steps

1.1: dilauroyl peroxide / 1,2-dichloro-ethane / Heating

2.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

2.2: 65 percent / hexane; tetrahydrofuran / 3.5 h / 20 °C

With n-butyllithium; dilauryl peroxide; In tetrahydrofuran; hexane; 1,2-dichloro-ethane;
DOI:10.1039/b411158c

Reference yield:

: 3377-92-2,26715-88-8
vinyl pivalate

: 804498-92-8
4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lauroyl peroxide / 1,2-dichloro-ethane / Heating

2.1: dilauroyl peroxide / 1,2-dichloro-ethane / Heating

3.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

3.2: 65 percent / hexane; tetrahydrofuran / 3.5 h / 20 °C

With n-butyllithium; dilauryl peroxide; In tetrahydrofuran; hexane; 1,2-dichloro-ethane;
DOI:10.1039/b411158c

Reference yield:

: 1204-21-3
2-bromo-2',5'-dimethoxyacetophenone

: 804498-92-8
4-hydroxy-5,8-dimethoxy-4-(phenylethynyl)-1,2,3,4-tetrahydro-1-naphthalenyl pivalate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 95 percent / acetone / 1 h / 0 °C

2.1: lauroyl peroxide / 1,2-dichloro-ethane / Heating

3.1: dilauroyl peroxide / 1,2-dichloro-ethane / Heating

4.1: n-BuLi / hexane; tetrahydrofuran / 0.5 h / -78 °C

4.2: 65 percent / hexane; tetrahydrofuran / 3.5 h / 20 °C

With n-butyllithium; dilauryl peroxide; In tetrahydrofuran; hexane; 1,2-dichloro-ethane; acetone;
DOI:10.1039/b411158c