N⁶-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine

Base Information

• Chemical Name: N⁶-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine
• CAS No.: 1054631-71-8
• Molecular Formula: C₁₈H₂₂N₆O₃
• Molecular Weight: 370.411
• Mol file: 1054631-71-8.mol

Synonyms:N⁶-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine

Chemical Property of N⁶-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine

There total 6 articles about N⁶-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-Trifluoro-N-{(2R,3R,4S,5R)-4-hydroxy-5-hydroxymethyl-2-[6-(2-methyl-benzylamino)-purin-9-yl]-tetrahydro-furan-3-yl}-acetamide → N6-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine (1054631-71-8)

Guidance literature:

With ammonium hydroxide; In ethanol; at 80 ℃; for 24h;

DOI:10.1021/jm000472o

Reference yield:

2'-amino-2'-deoxyadenosine (10414-81-0) → N6-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine (1054631-71-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 99 percent / adenosine deaminase; H₂O / 20 °C

2: dimethylformamide / 3 h / 60 °C

3: Et₃N; DMAP / acetonitrile / 1 h / 20 °C

4: 92 percent / POCl₃; Et₄NCl; N,N-dimethylaniline / acetonitrile / 0.17 h / 100 °C

5: Et₃N / ethanol / 18 h / 60 °C

6: aq. NH₃ / ethanol / 24 h / 80 °C

With dmap; ammonium hydroxide; tetraethylammonium chloride; water; N,N-dimethyl-aniline; triethylamine; adenosine deaminase; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm000472o

Reference yield:

2'-amino-2'-deoxyinosine (75763-51-8) → N6-(2-methylbenzyl)-2'-deoxy-2'-aminoadenosine (1054631-71-8)

Guidance literature:

Multi-step reaction with 5 steps

1: dimethylformamide / 3 h / 60 °C

2: Et₃N; DMAP / acetonitrile / 1 h / 20 °C

3: 92 percent / POCl₃; Et₄NCl; N,N-dimethylaniline / acetonitrile / 0.17 h / 100 °C

4: Et₃N / ethanol / 18 h / 60 °C

5: aq. NH₃ / ethanol / 24 h / 80 °C

With dmap; ammonium hydroxide; tetraethylammonium chloride; N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In ethanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm000472o

upstream raw materials:

2'-amino-2'-deoxyadenosine

2'-amino-2'-deoxyinosine

2'-deoxy-2'-trifluoroacetamidoinosine

9-[2'-deoxy-2'-trifluoroacetamido-3',5'-O-(diacetyl)]-(1-β-D-ribofuranosyl)-6-chloropurine