methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate

Base Information

Chemical Name:methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate
CAS No.:711020-43-8
Molecular Formula:C₃₃H₃₆Cl₂N₂O₅
Molecular Weight:611.565
Hs Code.:

Synonyms:methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate

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Chemical Property of methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate

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Technology Process of methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate

There total 5 articles about methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 367260-21-7
methyl 2-(bromomethyl)-3-cyano-1-naphthoate

: 711020-39-2
tert-butyl [(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl][(2R)-2-hydroxypropyl]carbamate

: 711020-43-8
methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate

Guidance literature:: With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 50 - 60 ℃;
DOI:10.1016/j.bmc.2004.03.015

Reference yield:

: 147643-57-0
(2S)-2-(3,4-dichlorophenyl)pent-4-enoic acid

: 711020-43-8
methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / N,N-diisopropylethylamine; 4-dimethylaminopyridine; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / Heating

2: lithium aluminum hydride / diethyl ether; tetrahydrofuran / Heating

3: sodium carbonate / dioxane; H₂O

4: 77 percent / sodium hydride / dimethylformamide; tetrahydrofuran / 50 - 60 °C

With dmap; lithium aluminium tetrahydride; sodium hydride; sodium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.03.015

Reference yield:

: 263862-16-4
methyl 3-cyano-2-methyl-1-naphthoate

: 711020-43-8
methyl 2-[((1R)-2-{(tert-butoxycarbonyl)[(2S)-2-(3,4-dichlorophenyl)pent-4-en-1-yl]amino}-1-methylethoxy)methyl]-3-cyano-1-naphthoate

Guidance literature:: Multi-step reaction with 2 steps

1: N-bromosuccinimide; 2,2'-azobis(2-methylisobutyronitrile) / CCl₄ / 3 h / Heating

2: 77 percent / sodium hydride / dimethylformamide; tetrahydrofuran / 50 - 60 °C

With N-Bromosuccinimide; 2,2'-azobis(2-methylisobutyronitrile); sodium hydride; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2004.03.015