Arg(N^gNO₂)-Gly-Asp(OBn)-Ser(Bn)-OBn

Base Information

• Chemical Name: Arg(N^gNO₂)-Gly-Asp(OBn)-Ser(Bn)-OBn
• CAS No.: 788808-61-7
• Molecular Formula: C₃₆H₄₄N₈O₁₀
• Molecular Weight: 748.793
• Mol file: 788808-61-7.mol

Synonyms:Arg(N^gNO₂)-Gly-Asp(OBn)-Ser(Bn)-OBn

Chemical Property of Arg(N^gNO₂)-Gly-Asp(OBn)-Ser(Bn)-OBn

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Arg(N^gNO₂)-Gly-Asp(OBn)-Ser(Bn)-OBn

There total 9 articles about Arg(N^gNO₂)-Gly-Asp(OBn)-Ser(Bn)-OBn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-Arg(NgNO2)-Gly-Asp(OBn)-Ser(Bn)-OBn (246516-47-2) → Arg(NgNO2)-Gly-Asp(OBn)-Ser(Bn)-OBn (788808-61-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 3h;

DOI:10.1021/jm000295r

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → Arg(NgNO2)-Gly-Asp(OBn)-Ser(Bn)-OBn (788808-61-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 89.5 percent / DPPA; Et₃N / dimethylformamide / 22 h / 20 °C

2: 2 M HCl / dioxane / 3 h / 20 °C

3: 90.2 percent / DPPA; Et₃N / dimethylformamide / 22 h / 20 °C

4: 2 M HCl / dioxane / 3 h / 20 °C

5: Et₃N / tetrahydrofuran / 22 h / 20 °C

6: HCl / dioxane / 3 h / 20 °C

With hydrogenchloride; diphenyl-phosphinic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm000295r

Reference yield:

N-alpha-t-butoxycarbonyl-Ng-nitroarginine (2188-18-3) → Arg(NgNO2)-Gly-Asp(OBn)-Ser(Bn)-OBn (788808-61-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N / tetrahydrofuran / 0.17 h / -15 °C

2: Et₃N / tetrahydrofuran / 22 h / 20 °C

3: HCl / dioxane / 3 h / 20 °C

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane;

DOI:10.1021/jm000295r

upstream raw materials:

Boc-Arg(N^gNO₂)-Gly-Asp(OBn)-Ser(Bn)-OBn

BOC-L-aspartic acid 4-benzyl ester

N-alpha-t-butoxycarbonyl-Ng-nitroarginine

(S)-benzyl 2-amino-3-(benzyloxy)propanoate hydrochloride