2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one

Base Information

Chemical Name:2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one
CAS No.:1187758-78-6
Molecular Formula:C₁₇H₁₂O₃S
Molecular Weight:296.346
Hs Code.:

Synonyms:2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one

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Chemical Property of 2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one

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Technology Process of 2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one

There total 5 articles about 2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187758-73-1
methyl 2-hydroxy-2-(4-oxo-3-phenyl-4H-thiochromen-2-yl)acetate

: 1187758-78-6
2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 ℃; Inert atmosphere;

Reference yield:

: 140173-38-2
3-iodo-2-methyl-4H-benzothiopyran-4-one

: 1187758-78-6
2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C / Inert atmosphere

2.1: N,N,N,N,N,N-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

2.2: 0.5 h

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

3.2: Davis reagent / 0.5 h

4.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; n-butyllithium; potassium carbonate; diisopropylamine; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide;

Reference yield:

: 771-40-4
2-methyl-4H-thiochromen-4-one

: 1187758-78-6
2-(1-formyl-1-hydroxymethyl)-3-phenyl-4H-thiochromen-4-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; cerium(IV)diammonium nitrate / acetonitrile / 4 h / 60 °C / Inert atmosphere

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide; water / 4 h / 80 °C / Inert atmosphere

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide; diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / -78 °C / Inert atmosphere

3.2: 0.5 h

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

4.2: Davis reagent / 0.5 h

5.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C / Inert atmosphere

With N,N,N,N,N,N-hexamethylphosphoric triamide; cerium(IV)diammonium nitrate; lithium aluminium tetrahydride; n-butyllithium; iodine; potassium carbonate; diisopropylamine; lithium hexamethyldisilazane; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; hexane; water; N,N-dimethyl-formamide; acetonitrile;